Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep871 | Reproductive and Developmental Endocrinology | ECE2022

Endometrial cell-type-specific disease signatures and endometrial organoids in polycystic ovary syndrome

Eriksson Gustaw , Li Congru , Pui Han-Pin , Risal Sanjiv , Hirschberg Angelica Linde n , Petropoulos Sophie , Deng Qiaolin , Stener-Victorin Elisabet

Introduction: Polycystic ovary syndrome (PCOS) is the leading cause of female infertility and is associated with high degree of comorbidities including type 2 diabetes and endometrial cancer. Hyperandrogenemia is a hallmark of PCOS and contributes to endometrial-related dysfunctions, including implantation failure and miscarriage. Whether cellular heterogeneity contributes to the functioning of the endometrium is not previously studied. Therefore, the aim is to reveal cell-typ...